Bach V T, Thadepalli H
Chemotherapy. 1980;26(5):344-53. doi: 10.1159/000237926.
589 isolates of anaerobic bacteria, including 127 isolates of Bacterioides fracilis, were tested against 23 antimicrobial agents. At their usually achievable serum levels, carbenicillin, ticarcillin, mezlocillin and piperacillin; cefoxitin, minocycline, doxycycline, clindamycin, chloramphenicol and rifampin were effective against more than 80% of B. fragilis isolates. At usual therapeutic doses, penicillin (PEN), ampicillin (AMP), cyclacillin (CYC), cephalothin (CT), cefazolin (CZ), cephradine (CPD), cefamandole (CMD), cefaclor (CCL), cefuroxime (CRX), spectinomycin (SPT), tetracycline (TET), ethambutol (EMB) and isoniazid (INH) were ineffective against B. Fragilis. However, high and clinically tolerated doses of PEN, CMD and SPT inhibited more than 80% of B. fragilis isolates, but AMP, CYC, CT, CZ, CPD, CCL and CRX, TET, EMB and INH remained totally ineffective against B. fragilis. The therapeutic merits of these antibiotics are discussed.
对589株厌氧菌（包括127株脆弱拟杆菌）进行了23种抗菌药物的测试。在通常可达到的血清水平下，羧苄西林、替卡西林、美洛西林和哌拉西林；头孢西丁、米诺环素、多西环素、克林霉素、氯霉素和利福平对80%以上的脆弱拟杆菌菌株有效。在常用治疗剂量下，青霉素（PEN）、氨苄西林（AMP）、环青霉素（CYC）、头孢噻吩（CT）、头孢唑林（CZ）、头孢拉定（CPD）、头孢孟多（CMD）、头孢克洛（CCL）、头孢呋辛（CRX）、大观霉素（SPT）、四环素（TET）、乙胺丁醇（EMB）和异烟肼（INH）对脆弱拟杆菌无效。然而，高剂量且临床可耐受的PEN、CMD和SPT可抑制80%以上的脆弱拟杆菌菌株，但AMP、CYC、CT、CZ、CPD、CCL和CRX、TET、EMB和INH对脆弱拟杆菌仍然完全无效。讨论了这些抗生素的治疗价值。
