Liepa G U, Masoro E J, Bertrand H A, Yu B P
Am J Physiol. 1980 Mar;238(3):E253-7. doi: 10.1152/ajpendo.1980.238.3.E253.
Fischer 344 male rats were either fed ad libitum or 60% of the ad libitum intake. The restriction of food intake markedly increased the median length of life. Postabsorptive serum cholesterol and phospholipid concentrations increase in the ad libitum-fed rats with increasing age. Life-prolonging food restriction does not influence the serum levels of these lipids in young rats but delays the age-related increase in concentrations. Postabsorptive serum free fatty acid (FFA) concentrations decrease with advancing age in ad libitum-fed rats. Life-prolonging food restriction, while not affecting the serum FFA levels in young rats, delays and possibly partially prevents the age-related decrease in concentration. Food restriction lowers postabsorptive serum triglyceride levels at all ages studied. The data on serum cholesterol, phospholipids, and FFA provide further evidence that food restriction delays age-related changes in the physiological systems of rats. This delay of physiological decline may well retard the occurrence of age-related disease processes, thus prolonging life.
将Fischer 344雄性大鼠分为自由采食组或自由采食量60%的限食组。食物摄入量的限制显著延长了中位寿命。自由采食的大鼠随着年龄增长，吸收后血清胆固醇和磷脂浓度增加。延长寿命的食物限制对年轻大鼠的这些血脂水平没有影响，但延缓了与年龄相关的浓度升高。自由采食的大鼠吸收后血清游离脂肪酸（FFA）浓度随着年龄增长而降低。延长寿命的食物限制虽然不影响年轻大鼠的血清FFA水平，但延缓并可能部分阻止了与年龄相关的浓度降低。在所有研究年龄中，食物限制均降低了吸收后血清甘油三酯水平。关于血清胆固醇、磷脂和FFA的数据进一步证明，食物限制延缓了大鼠生理系统与年龄相关的变化。这种生理衰退的延迟很可能会延缓与年龄相关疾病进程的发生，从而延长寿命。
