Zierdt C H, Robertson E A, Williams R L, MacLowry J D
Appl Environ Microbiol. 1980 Mar;39(3):623-9. doi: 10.1128/aem.39.3.623-629.1980.
Computer analysis of Staphylococcus aureus phage ty ping data collected for over 18 years in a large research hospital showed a drastic decrease in the number of hospital epidemic strains. Phage lysis patterns gradually modified from those of earlier years and were a reflection of changes within the S. aureus reservoir, and not within the typing phages, since the typing phages were used from stable lyophilized stocks. There was increasing cross-lysis of S. aureus strains by phages of lytic groups I, II, and III, such that this grouping was no longer epidemiologically valid. A 61% increase in unique strains occurred from the period 1957 to 1975. Disappearance of the widely recognized epidemic strains was followed by a proliferation of unique strains with individual phage patterns. These increased from 38% in the period 1957 to 1962 to 62% in the period 1969 to 1975, indicating a trend toward a "one patient-one strain" situation. Nontypable strains decreased in more recent years from 16% (1957 to 1975) to 7% in 1978, following introduction of phages 94, 96, 292, and D-11. Pandemic S. aureus strain 80/81 first appeared in this hospital in 1959, 5 years after it was first reported in the United States. Strain 80/81 disappeared from the hospital in 1963, partly due to the advent of methicillin.
对一家大型研究医院18年多来收集的金黄色葡萄球菌噬菌体分型数据进行的计算机分析显示，医院流行菌株的数量急剧下降。噬菌体裂解模式逐渐从早期的模式发生改变，这反映了金黄色葡萄球菌库内的变化，而非分型噬菌体的变化，因为分型噬菌体使用的是稳定的冻干菌株。I、II和III裂解组的噬菌体对金黄色葡萄球菌菌株的交叉裂解越来越多，以至于这种分组在流行病学上不再有效。1957年至1975年期间，独特菌株增加了61%。广泛认可的流行菌株消失后，出现了具有独特噬菌体模式的独特菌株的增殖。这些菌株从1957年至1962年期间的38%增加到1969年至1975年期间的62%，表明有朝着“一个患者一种菌株”情况发展的趋势。近年来，在引入噬菌体94、96、292和D - 11后，不可分型菌株从1957年至1975年期间的16%降至1978年的7%。大流行的金黄色葡萄球菌菌株80/81于1959年首次在这家医院出现，这是在美国首次报告该菌株5年后。80/81菌株于1963年从该医院消失，部分原因是甲氧西林的出现。
