Zierdt C H
J Clin Microbiol. 1982 Sep;16(3):517-20. doi: 10.1128/jcm.16.3.517-520.1982.
Staphylococcus aureus colonization of 326 predominantly chronic-care (long-term) patients was studied for 24 years. There were 5,827 upper respiratory cultures positive for S. aureus, ranging from 10 to 88 per patient, determined by the number of years (1 to 21; average, 4.6) that the patient was studied. Patients on the average carried 2.8 S. aureus strains. One patient carried eight strains. Each patient had a predominant strain. Predominant strains tended to be permanent, with 87% persistence over the studied years. Lytic group III strains were more than twice as frequent as group I strains and eight times as frequent as group II strains. Patient carriage of multiple S. aureus strains was usual. A collection of large numbers of cultures over an extended period was necessary for this statistical study, since cultures positive for predominant strains were interspersed with negative cultures and cultures positive for minor strains. Thus, persistence of carriage of a predominant S. aureus strain in a patient continues despite frequent negative cultures and cultures positive for minor strains.
对326名主要为慢性病护理（长期护理）患者的金黄色葡萄球菌定植情况进行了24年的研究。共有5827份上呼吸道培养物检测出金黄色葡萄球菌呈阳性，每位患者的阳性培养物数量从10份到88份不等，这取决于对患者进行研究的年限（1至21年；平均4.6年）。患者平均携带2.8株金黄色葡萄球菌。有一名患者携带了8株菌株。每位患者都有一株优势菌株。优势菌株往往具有持久性，在研究的数年中持久性为87%。溶菌性III组菌株的出现频率是I组菌株的两倍多，是II组菌株的八倍。患者携带多种金黄色葡萄球菌菌株是常见现象。由于优势菌株的阳性培养物与阴性培养物以及次要菌株的阳性培养物相互穿插，因此进行这项统计研究需要在较长时间内收集大量培养物。因此，尽管经常出现阴性培养物和次要菌株的阳性培养物，但患者体内优势金黄色葡萄球菌菌株的携带情况仍会持续存在。
