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接触性超敏反应中的巨噬细胞抑制因子。其释放及作用机制。

Macrophage suppressor factor in contact sensitivity. Mechanisms of its release and action.

作者信息

Marcinkiewicz J, Ptak W

出版信息

Immunology. 1980 Sep;41(1):211-6.

PMID:6448807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458240/
Abstract

An antigen-specific suppressor factor (TSF) produced by mouse T lymphocytes prevents immune cells from conferring adoptive immunity on normal recipients. This TSF attaches easily to the macrophage surface, and these 'armed' macrophages in the presence of a corresponding antigen manufacture (in vitro) a non-specific macrophage suppressor factor (MSF) which impairs the activity of cells sensitized to homologous or heterologous antigens. Our experiments show that MSF is temperature- and trypsin-sensitive, and is not a prostaglandin. Its molecular weight is in the range of 10 kD. MSF is synthesized by macrophages de novo subsequent to triggering by TSF and antigen. MSF impairs only the activity of cells mediating contact sensitivity reaction (Ly 1) but has no influence on T-suppressor cells (Ly 23). The possibility that MSF is an enzyme is discussed.

摘要

小鼠T淋巴细胞产生的一种抗原特异性抑制因子（TSF）可阻止免疫细胞赋予正常受体过继性免疫。这种TSF很容易附着于巨噬细胞表面，并且这些“武装”巨噬细胞在相应抗原存在的情况下（体外）产生一种非特异性巨噬细胞抑制因子（MSF），该因子会损害对同源或异源抗原致敏的细胞的活性。我们的实验表明，MSF对温度和胰蛋白酶敏感，且不是前列腺素。其分子量在10 kD范围内。MSF是巨噬细胞在TSF和抗原触发后重新合成的。MSF仅损害介导接触敏感性反应的细胞（Ly 1）的活性，但对T抑制细胞（Ly 23）没有影响。文中讨论了MSF是一种酶的可能性。

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本文引用的文献

1
The requirement for T lymphocyte-specific suppressor factors and corresponding antigen in the production of nonspecific suppressor monokines by macrophages.巨噬细胞产生非特异性抑制性单核因子过程中对T淋巴细胞特异性抑制因子及相应抗原的需求。
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4
Suppression of contact sensitivity by T cells in the mouse. I. Demonstration that suppressor cells act on the effector stage of contact sensitivity; and their induction following in vitro exposure to antigen.小鼠中T细胞对接触敏感性的抑制作用。I. 证明抑制细胞作用于接触敏感性的效应阶段；以及它们在体外暴露于抗原后的诱导产生。
Proc R Soc Lond B Biol Sci. 1974 Nov 5;187(1088):329-48. doi: 10.1098/rspb.1974.0078.
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The regulation of lymphocyte functions by the macrophage.巨噬细胞对淋巴细胞功能的调节
Immunol Rev. 1978;40:227-55. doi: 10.1111/j.1600-065x.1978.tb00408.x.
6
Nonspecific macrophage suppressor factor: its role in the inhibition of contact sensitivity to picryl chloride by specific T suppressor factor.非特异性巨噬细胞抑制因子：其在特异性T抑制因子对苦味酰氯接触敏感性抑制中的作用。
Eur J Immunol. 1978 Sep;8(9):645-9. doi: 10.1002/eji.1830080908.
7
Role of macrophages in the immune response.巨噬细胞在免疫反应中的作用。
Immunol Rev. 1978;40:1-255.
8
On soluble mediators of immunologic regulation.
Cell Immunol. 1976 Jan;21(1):161-76. doi: 10.1016/0008-8749(76)90337-3.

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