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1
Correlation between mixed lymphocyte culture and phytohaemagglutinin stimulation responses of human lymphocytes.人淋巴细胞混合淋巴细胞培养与植物血凝素刺激反应之间的相关性。
Clin Exp Immunol. 1980 Jul;41(1):173-5.
2
Age-related changes in PHA and allogeneic reactivity of human T lymphocytes.人类T淋巴细胞的PHA和同种异体反应性的年龄相关变化。
Arch Immunol Ther Exp (Warsz). 1983;31(1):33-8.
3
[3H-thymidine paper strip modification of the lymphocyte transformation test. III. Whole blood lymphocyte mixed culture using a cryopreserved stimulating cell mixture].[3H-胸腺嘧啶核苷纸条法对淋巴细胞转化试验的改进。III. 使用冷冻保存的刺激细胞混合物进行全血淋巴细胞混合培养]
Acta Biol Med Ger. 1980;39(10):1045-50.
4
Age dependence of subpopulations and functions of human peripheral lymphocytes.人类外周淋巴细胞亚群及功能的年龄依赖性
J Clin Lab Immunol. 1981 Jan;5(1):47-51.
5
[Responsiveness of lymphocytes to stimulation by pha and autologous blasts in acute lymphatic leukemias during remission (author's transl)].急性淋巴细胞白血病缓解期淋巴细胞对PHA和自体母细胞刺激的反应性（作者译）
Padiatr Padol. 1976;11(2-2):364-8.
6
Inhibition of mitogen and specific antigen-induced human lymphocyte proliferation by cadmium.
Exp Cell Biol. 1981;49(1):15-9.
7
Regulatory role of lysosomal enzymes in rat lymphocyte reactivity in vitro.溶酶体酶在大鼠淋巴细胞体外反应性中的调节作用。
Arch Immunol Ther Exp (Warsz). 1981;29(3):337-40.
8
T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.间充质干细胞介导的T细胞抑制在重型再生障碍性贫血患者中存在缺陷。
Exp Hematol. 2005 Jul;33(7):819-27. doi: 10.1016/j.exphem.2005.05.006.
9
Age-dependent responsiveness of T lymphocytes to allogeneic and PHA stimulation.T淋巴细胞对同种异体和PHA刺激的年龄依赖性反应性。
Thymus. 1980 Jan;1(4-5):205-13.
10
Immunoregulation and apoptosis induction of nitric oxide in the human mixed lymphocytes culture.一氧化氮在人混合淋巴细胞培养中的免疫调节与凋亡诱导作用
Transplant Proc. 2006 Dec;38(10):3211-3. doi: 10.1016/j.transproceed.2006.10.170.

本文引用的文献

1
Activation of human T and B lymphocytes by polyclonal mitogens.多克隆有丝分裂原对人T淋巴细胞和B淋巴细胞的激活作用。
Nature. 1974 Apr 19;248(5450):698-701. doi: 10.1038/248698a0.
2
A rapid micro-method for the phytohaemagglutinin-induced human lymphocyte transformation test.一种用于植物血凝素诱导的人淋巴细胞转化试验的快速微量方法。
Clin Exp Immunol. 1974 Sep;18(1):155-67.
3
Synergy between human T and B lymphocytes in their response to phythaemagglutinin and pokeweed mitogen.人T淋巴细胞和B淋巴细胞在对植物血凝素和商陆有丝分裂原反应中的协同作用。
Immunology. 1976 Aug;31(2):273-81.
4
Quantitation of pretransplantation immune responsiveness by in vitro T-cell testing.通过体外T细胞检测对移植前免疫反应性进行定量分析。
Transplant Proc. 1977 Mar;9(1):49-53.
5
Mixed-lymphocyte culture response in a related and an unrelated Australian population.
Med J Aust. 1979 Nov 17;2(10):518-21. doi: 10.5694/j.1326-5377.1979.tb127143.x.
6
Correlation of MLC response with graft survival in cadaver and related donor kidney transplants.尸体及相关供体肾移植中MLC反应与移植肾存活的相关性。
Transplant Proc. 1978 Dec;10(4):949-51.
7
Correlation between magnitude of MLC and kidney graft survival in intrafamilial transplantation.家族内移植中MLC强度与肾移植存活率的相关性。
Tissue Antigens. 1977 Nov;10(5):364-72. doi: 10.1111/j.1399-0039.1977.tb00772.x.
8
MLR-R and MLR-S gene products are expressed on different lymphoid cells.
Transplantation. 1977 Jul;24(1):63-9. doi: 10.1097/00007890-197707000-00009.
9
Significance of mixed leukocyte culture testing in cadaver kidney transplantation.混合白细胞培养试验在尸体肾移植中的意义
Transplantation. 1977 Apr;23(4):375-80. doi: 10.1097/00007890-197704000-00012.
10
Transformation of lymphocytes from patients awaiting cadaver renal transplants.等待尸体肾移植患者淋巴细胞的转化
Lancet. 1976 Sep 11;2(7985):529-31. doi: 10.1016/s0140-6736(76)91790-6.

人淋巴细胞混合淋巴细胞培养与植物血凝素刺激反应之间的相关性。

Correlation between mixed lymphocyte culture and phytohaemagglutinin stimulation responses of human lymphocytes.

作者信息

Nanra S K, Boettcher B

出版信息

Clin Exp Immunol. 1980 Jul;41(1):173-5.

PMID:6449330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536917/
Abstract

In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunction with the results of other tests for T cell parameters, in a transplant programme to predict favourable outcome and to monitor immunosuppressive therapy.

摘要

在57名健康个体中，已发现其淋巴细胞对PHA刺激的反应与对混合淋巴细胞培养（MLC）中淋巴细胞刺激的反应之间存在显著相关性（r = 0.3，P < 0.05）。有人提出，这些检测可量化个体T细胞反应性的总体状态，并可在移植计划中与其他T细胞参数检测结果结合使用，以预测良好结局并监测免疫抑制治疗。