体重和性别作为大鼠发热发展的决定因素。

Body mass and sex as determining factors in the development of fever in rats.

Ford D M, Klugman K P

J Physiol. 1980 Jul;304:43-50. doi: 10.1113/jphysiol.1980.sp013308.

Abstract

We have investigated the effect of a single I.P. injection (20 microgram/kg) of bacterial endotoxin on rectal temperature in rats of both sexes and from a wide range of body mass. 2. In male rats, endotoxin produced a monophasic or a biphasic rise in temperature, or a monophasic fall. 3. The extent of the rise in rectal temperature in male rats is related to body mass. There is a statistically significant correlation between body mass and the mean change in temperature measured over 100 min after injection of endotoxin. 4. In the female rats, endotoxin produced a monophasic fall in rectal temperature. The extent of the fall was not significantly correlated with body mass. 5. We suggest that the effect of endotoxin in male rats is determined by the physical relationship between body mass and surface area, because larger animals developed greater fevers. 6. The difference between the effect of endotoxin in male and female rats may have a physiological explanation and may involve differences in susceptibility to cutaneous vasodilation occurring immediately after injection of endotoxin.

摘要

我们研究了单次腹腔注射（20微克/千克）细菌内毒素对不同性别、不同体重大鼠直肠温度的影响。2. 在内毒素作用下，雄性大鼠体温出现单相或双相升高，或单相下降。3. 雄性大鼠直肠温度升高的幅度与体重有关。注射内毒素后100分钟内测得的体重与平均体温变化之间存在统计学上的显著相关性。4. 在内毒素作用下，雌性大鼠直肠温度出现单相下降。下降幅度与体重无显著相关性。5. 我们认为，内毒素对雄性大鼠的影响取决于体重与体表面积之间的物理关系，因为较大的动物发热更明显。6. 内毒素对雄性和雌性大鼠作用的差异可能有生理学解释，可能涉及注射内毒素后立即发生的皮肤血管舒张易感性差异。