Fuchs T, Hammarström L, Smith C I, Brundin J
Acta Obstet Gynecol Scand. 1980;59(4):355-9. doi: 10.3109/00016348009154093.
Human chorionic gonadotropin (HCG) has previously been considered to be immunosuppressive and, thus, by prohibiting maternal rejection of the fetal transplant, to be one of the factors responsible for the successful outcome of pregnancy. The mechanism by which HCG exerts its pregnancy retaining effect is, however, as yet unknown. The present study shows that HCG has the capacity in mice of inducing lymphocytes which are subsequently competent to depress a polyclonal antibody response induced by different B cell mitogens. It is therefore suggested that HCG may exert its feto-protective action by inducing suppressor T cells. These lymphocytes would thus prevent the activation of cells which are responsible for transplant rejection.
人绒毛膜促性腺激素（HCG）此前被认为具有免疫抑制作用，因此，通过阻止母体对胎儿移植的排斥反应，它被认为是妊娠成功结局的因素之一。然而，HCG发挥其维持妊娠作用的机制尚不清楚。本研究表明，HCG在小鼠体内具有诱导淋巴细胞的能力，这些淋巴细胞随后能够抑制由不同B细胞有丝分裂原诱导的多克隆抗体反应。因此，有人提出，HCG可能通过诱导抑制性T细胞发挥其对胎儿的保护作用。这些淋巴细胞因此会阻止负责移植排斥反应的细胞被激活。
