Beck D, Ginsburg H, Naot Y
Am J Obstet Gynecol. 1977 Sep 1;129(1):14-20. doi: 10.1016/0002-9378(77)90811-0.
Human chorionic gonadotropin (HCG) produced by fetal trophoblastic cells was suggested to play a role in the suppression of maternal lymphocyte response against the fetal allograft. Reports supporting this concept have demonstrated a suppressive effect of crude HCG on lymphocyte blastogenesis. However, similar doses of purified hormone preparations were unable to inhibit lymphocyte stimulation with mitogens. A modulating influence of phenol-free and immunoglobulin-free HCG preparation on lymphocyte blastogenesis is presented. Enhanced lymphocyte stimulation with various mitogens occurred in cultures supplemented with HCG at low doses. On the other hand, higher hormone concentration exerted an inhibitory effect on lymphocyte blastogenesis. An increase in lymphoid cell concentrations was demonostrated in cultures supplemented with the hormone preparation. These observations are compatible with the suggested role of HCG in the maternal tolerance toward a histoincompatible fetus.
有人提出，胎儿滋养层细胞产生的人绒毛膜促性腺激素（HCG）在抑制母体淋巴细胞对胎儿同种异体移植物的反应中发挥作用。支持这一概念的报告表明，粗制HCG对淋巴细胞增殖有抑制作用。然而，类似剂量的纯化激素制剂无法抑制有丝分裂原对淋巴细胞的刺激。本文介绍了无酚和无免疫球蛋白的HCG制剂对淋巴细胞增殖的调节作用。在添加低剂量HCG的培养物中，各种有丝分裂原对淋巴细胞的刺激增强。另一方面，较高的激素浓度对淋巴细胞增殖有抑制作用。在添加激素制剂的培养物中，淋巴细胞浓度有所增加。这些观察结果与HCG在母体对组织不相容胎儿的耐受性中所起的作用相符。
