大面积烧伤患者淋巴细胞反应性的纵向分析。
Longitudinal assay of lymphocyte responsiveness in patients with major burns.
作者信息
Munster A M, Winchurch R A, Birmingham W J, Keeling P
出版信息
Ann Surg. 1980 Dec;192(6):772-5. doi: 10.1097/00000658-198012000-00013.
Abstract
Serial blast transformation in vitro was measured in peripheral lymphocytes from 38 patients with major thermal injury. Lymphocytes were tested with the antigens streptokinase-streptodornase (SKSD), mumps and purified protein derivative (PPD), the mitogens concanavalin A (Con A) and phytohemagglutinin (PHA), and in the one-way mixed lymphocyte reaction. Statistically significant suppression by the burn injury was noticed in all measurements except response to PHA. One-time measurements were not significantly different between the patients who survived and the patients who did not survive their burn injuries. However, serial determinations of responsiveness to the three natural antigens SKSD, mumps and PPD, as well as the mixed lymphocyte reaction accurately reflected prognosis.
摘要
对38例重度热损伤患者外周血淋巴细胞进行体外连续增殖转化检测。用链激酶 - 链道酶（SKSD）、腮腺炎病毒和结核菌素纯蛋白衍生物（PPD）抗原、促有丝分裂原刀豆球蛋白A（Con A）和植物血凝素（PHA）对淋巴细胞进行检测，并进行单向混合淋巴细胞反应。除对PHA的反应外，在所有检测中均发现烧伤对淋巴细胞增殖转化有统计学意义的抑制作用。存活患者与未存活患者的一次性检测结果无显著差异。然而，对三种天然抗原SKSD、腮腺炎病毒和PPD以及混合淋巴细胞反应的反应性连续测定准确反映了预后。
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