Wilson M A, Pollack M J
J Nucl Med. 1981 Jun;22(6):518-21.
In a 12-mo study period, there were 14 days identified when the stomach was visualized in routine bone imaging. On these days, 44% of the 110 patients imaged demonstrated this effect. Only the quality control, binding efficiency, and scan quality differed (p less than 0.005) when the study population was compared with a reference population of 162 patients. However, on the days when this effect was noted, there was a significant (p less than 0.001) linear correlation between the presence and degree of gastric visualization and the radiopharmaceutical incubation and quality control parameters. The study suggests a sporadic phenomenon that appears to result from partial oxidation of the agent during incubation, producing (a) different species of labeled diphosphonate that display altered affinity for bone (scan quality) and (b) free pertechnetate (gastric activity).
在为期12个月的研究期间，在常规骨显像中发现有14天胃显影。在这些日子里，接受显像的110名患者中有44%出现了这种情况。与162名患者的参考人群相比，仅在质量控制、结合效率和扫描质量方面存在差异（p小于0.005）。然而，在发现这种情况的日子里，胃显影的存在和程度与放射性药物孵育及质量控制参数之间存在显著的（p小于0.001）线性相关性。该研究表明这是一种偶发现象，似乎是由于孵育期间试剂的部分氧化导致的，产生了（a）对骨显示出改变亲和力的不同种类的标记二膦酸盐（扫描质量）和（b）游离高锝酸盐（胃内活性）。
