Wang T S, Mojdehi G E, Fawwaz R A, Johnson P M
J Nucl Med. 1979 Oct;20(10):1066-70.
The study was undertaker to evaluate the effect on bone localization of substitutions at the bridge carbon atom of methylenediphosphonic acid. Two monosubstituted compounds (ethylidenediphosphonic acid and benzylmethylenediphosphonic acid), and one disubstituted compound (isopropylidenediphosphonic acid), were synthesized. The biological behavior was compared with that of MDP and dichloro-MDP in the rat, using Tc-99m as a label. Ethylidenediphosphonic acid showed the highest femur-to-liver and femur-to-muscle ratios. MDP exhibited a slightly faster blood clearance than ethylidenediphosphonic acid.
该研究旨在评估亚甲基二膦酸桥碳原子上的取代基对骨定位的影响。合成了两种单取代化合物（乙叉二膦酸和苄基亚甲基二膦酸）以及一种双取代化合物（异丙叉二膦酸）。以Tc-99m作为标记物，在大鼠体内将其生物学行为与亚甲基二膦酸盐（MDP）和二氯-MDP的生物学行为进行比较。乙叉二膦酸显示出最高的股骨与肝脏以及股骨与肌肉的比值。MDP的血液清除速度比乙叉二膦酸略快。
