急性给予乙烷羟基二膦酸盐（EHDP）对大鼠用锝-99m亚甲基二膦酸盐（Tc-MDP）进行骨骼闪烁显像的影响。
Effects of acute administration of ethane hydroxydiphosphonate (EHDP) on skeletal scintigraphy with technetium-99m methylene diphosphonic acid (Tc-MDP) in the rat.
作者信息
Watt I, Hill P
出版信息
Br J Radiol. 1981 Jul;54(643):592-6. doi: 10.1259/0007-1285-54-643-592.
PMID:6455174
Abstract
A study has been performed in the rat to assess the effect of EHDP on the distribution of 99Tcm-labelled MDP used for skeletal imaging. Profound alterations in bone, kidney and blood levels were observed. These observations cast doubt on the value of bone scans for monitoring the therapeutic effect of diphosphonates.
摘要
在大鼠身上进行了一项研究，以评估依替膦酸二钠（EHDP）对用于骨骼成像的99锝标记亚甲基二膦酸盐（MDP）分布的影响。观察到骨骼、肾脏和血液水平出现了显著变化。这些观察结果使人对骨扫描监测双膦酸盐治疗效果的价值产生怀疑。
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