血浆置换对免疫复合物疾病患者体外单核细胞功能的影响。
The effect of plasma exchange on the in vitro monocyte function of patients with immune complex diseases.
作者信息
Steven M M, Tanner A R, Holdstock G E, Cockerell R, Smith J, Smith D S, Hamblin T J, Wright R
出版信息
Clin Exp Immunol. 1981 Aug;45(2):240-5.
In vitro function tests were performed on peripheral blood monocytes isolated from patients with putative immune complex diseases undergoing therapeutic plasma exchange. Bacterial killing by monocytes improved significantly after plasma exchange (pre: 29 +/- 5%; post: 39 +/- 3%). The intracellular content of the acid hydrolase N-acetylglucosaminidase (NAG) after in vitro culture rose significantly following plasma exchange (pre: 48.3 +/- 21 nmol mg protein-1 hr-1; post: 76.6 +/- 30.6), although the amount of NAG released into the supernatant was unchanged. Plasma exchange also resulted in reduced levels of immune complexes (IC) and clinical improvement in most patients. The beneficial effect of plasma exchange in patients with IC diseases may be partly due to removal of IC which are known to influence the functional activity of cells of the mononuclear macrophage series.
对接受治疗性血浆置换的疑似免疫复合物疾病患者分离出的外周血单核细胞进行了体外功能测试。血浆置换后，单核细胞的细菌杀伤能力显著提高（置换前：29±5%；置换后：39±3%）。体外培养后，酸性水解酶N - 乙酰葡糖胺酶（NAG）的细胞内含量在血浆置换后显著升高（置换前：48.3±21 nmol mg蛋白-1小时-1；置换后：76.6±30.6），尽管释放到上清液中的NAG量没有变化。血浆置换还导致大多数患者的免疫复合物（IC）水平降低且临床症状改善。血浆置换对IC疾病患者的有益作用可能部分归因于去除了已知会影响单核巨噬细胞系列细胞功能活性的IC。
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