人类自体反应性T细胞的特异性和功能。
Specificity and function of a human autologous reactive T cell.
作者信息
Hausman P B, Stobo J D
出版信息
J Exp Med. 1979 Jun 1;149(6):1537-42. doi: 10.1084/jem.149.6.1537.
Abstract
Normal human peripheral blood contains a population of T cells (autologous reactive cells [ARC]) capable of proliferating in response to signals from autologous B cells and monocytes. Selective suicide of proliferating ARC with 5-bromo-2-deoxyuridine and light demonstrated that this ARC was responsive to signals coded for by genes more closely linked to the HLA-DR, than to the HLA-A, or HLA-B, loci. Density-gradient fractionation of T cells indicated that populations enriched in ARC reactivity were also enriched for helper influences required for Ig synthesis by autologous B cells. In contrast, populations negatively selected for proliferating ARC were deficient in helper activity. These studies indicate that the ARC is responsive, at least in part, to products of genes closely linked to the HLA-DR locus and can function as a helper cell.
摘要
正常人类外周血含有一群T细胞（自身反应性细胞[ARC]），它们能够响应来自自身B细胞和单核细胞的信号而增殖。用5-溴-2-脱氧尿苷和光照对增殖的ARC进行选择性自杀表明，这种ARC对与HLA-DR基因座相比，与HLA-A或HLA-B基因座更紧密连锁的基因编码的信号有反应。T细胞的密度梯度分级分离表明，富含ARC反应性的群体也富含自身B细胞合成Ig所需的辅助影响。相反，对增殖的ARC进行阴性选择的群体辅助活性不足。这些研究表明，ARC至少部分地对与HLA-DR基因座紧密连锁的基因产物有反应，并可作为辅助细胞发挥作用。
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