Lang-Yang H, Zubay G
Mol Gen Genet. 1981;183(3):514-7. doi: 10.1007/BF00268773.
The genes for the beta and beta' subunits of RNA polymerase, rpoB and rpoC, and the genes for the two ribosomal proteins, rplL and rplJ, are part of the beta operon. Although this operon and contains a single strong promoter, the genes of the operon are not always coordinately expressed in vivo. This has now been confirmed in vitro where the lack of coordinate expression has been shown to be correlated with the selective inhibition of rpoB and rpoC gene expression by RNa polymerase. Rifampicin, which stops the initiation of transcription, also relieves this autogenous inhibition of beta and beta' (beta beta') synthesis. The inhibitory action of RNA polymerase and its reversal by rifampicin most likely occurs at a posttranscriptional or translation level.
RNA聚合酶β和β'亚基的基因rpoB和rpoC，以及两种核糖体蛋白的基因rplL和rplJ，是β操纵子的一部分。尽管这个操纵子有一个单一的强启动子，但操纵子中的基因在体内并不总是协调表达。这一点现已在体外得到证实，在体外已表明缺乏协调表达与RNA聚合酶对rpoB和rpoC基因表达的选择性抑制相关。利福平可阻止转录起始，它也能解除对β和β'（ββ'）合成的这种自身抑制。RNA聚合酶的抑制作用及其被利福平逆转的情况很可能发生在转录后或翻译水平。
