Frank S B
J Am Acad Dermatol. 1982 Mar;6(3):373-7. doi: 10.1016/s0190-9622(82)70032-5.
The rabbit ear model has been proposed as a useful bioassay to establish the comedogenic and acnegenic qualities of chemical compounds and finished products, pharmaceutical and cosmetic, for topical application. This review highlights the many problems in performance of the test method, the absence of correlation with experience in the human, and, consequently, the serious limitations of the conclusions that can reasonably be drawn, especially for the clinical dermatologist.
兔耳模型已被提议作为一种有用的生物测定法，用于确定化学化合物以及制药和化妆品成品的致粉刺和致痤疮特性，以供局部应用。本综述强调了该测试方法在操作过程中存在的诸多问题，以及与人体实际情况缺乏相关性，因此，尤其是对于临床皮肤科医生而言，能合理得出的结论存在严重局限性。
