Vetter U, Gammert C, Pirsig W, Landolt A, Heinze E
Rhinology. 1984 Jun;22(2):125-31.
Growth activity in different areas of human septal cartilage was measured by in vitro incorporation of 35 S-labelled sulfate and 3 H-labelled thymidine in 6 acromegalic patients. Septal cartilage was obtained during transnasal hypophysectomy. The growth activities in the posterior area, which is situated anterior to the septo-ethmoidal junction were significantly enhanced compared to a control group of hormonally normal adults. Growth activities of the septal cartilage in the anterior free end and the suprapremaxillary area were not different in both groups. This indicates that growth hormone excess in acromegaly enhances human septal growth by stimulation of growth activities in the posterior area and not at the anterior free end and suprapremaxillary area.
通过体外掺入35S标记的硫酸盐和3H标记的胸腺嘧啶核苷，对6例肢端肥大症患者鼻中隔软骨不同区域的生长活性进行了测定。鼻中隔软骨是在经鼻垂体切除术中获取的。与激素水平正常的成年对照组相比，位于筛骨鼻中隔交界处前方的后部区域的生长活性显著增强。两组中鼻中隔软骨前游离端和上颌骨上区域的生长活性没有差异。这表明肢端肥大症中生长激素过量通过刺激后部区域而非前游离端和上颌骨上区域的生长活性来增强人类鼻中隔生长。
