用药实际时间对用胆茶碱治疗的哮喘儿童茶碱血药浓度的影响。
Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate.
作者信息
McKenzie S A, Baillie E, Godfrey S
出版信息
Arch Dis Child. 1978 Feb;53(2):167-8. doi: 10.1136/adc.53.2.167.
Abstract
Two dosage schedules, 8 mg/kg per dose daily and 10 mg/kg per dose tds of choline theophyllinate were evaluated in asthmatic children. The times of the doses were considered the most practical for use outside hospital. Theophylline levels were measured 2 hours after each dose and were satisfactory in both schedules. The levels before the first dose of the day were, however, unsatisfactory. We emphasis the desirability of measuring blood levels in any patient receiving a theophylline compound.
摘要
在哮喘儿童中评估了两种茶碱胆碱的给药方案，即每日每剂8毫克/千克和每日三次、每剂10毫克/千克。给药时间被认为是在院外使用时最实用的。每次给药后2小时测量茶碱水平，两种方案的结果均令人满意。然而，当日第一剂之前的水平并不理想。我们强调，对任何接受茶碱化合物治疗的患者进行血药浓度检测都是可取的。
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Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate.用药实际时间对用胆茶碱治疗的哮喘儿童茶碱血药浓度的影响。
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本文引用的文献
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J Pharmacol Exp Ther. 1949 Nov;97(3):283-91.
2
Study of theophylline plasma levels after oral administration of new theophylline compounds.新型茶碱化合物口服给药后茶碱血药浓度的研究。
Br Med J. 1957 Jul 13;2(5036):67-9. doi: 10.1136/bmj.2.5036.67.
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Pharmacologic effects of intravenously administered aminophylline in asthmatic children.静脉注射氨茶碱对哮喘儿童的药理作用。
J Pediatr. 1970 May;76(5):777-82. doi: 10.1016/s0022-3476(70)80305-5.
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Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.茶碱的药代动力学。在氨茶碱临床剂量调整中的应用。
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