超免疫后免疫反应倒置。HLA相关疾病发病机制中的可能机制。
Immune response inversion after hyperimmunisation. Possible mechanism in the pathogenesis of HLA-linked diseases.
作者信息
Young C R, Ebringer A, Archer J R
出版信息
Ann Rheum Dis. 1978 Apr;37(2):152-8. doi: 10.1136/ard.37.2.152.
Abstract
The crosstolerance hypothesis suggests that animals sharing antigens with some microorganisms will produce low antibody levels in the early part and high levels in the latter part of an infection. Antibody responses have been measured in high responder B10.M and B10.D2 mice and low responder C3H and A.Thy-1.1, as well as F1 hybrids (B10.M X A.Thy-1.1) and (B10.M X C3H/He), after repeated immunisation with the antigen ferritin, involving altogether 483 mice. An inversion in the immune response was found to occur and similar delayed high antibody responses have been described in rheumatic fever. It is suggested a mechanism of immune inversion may operate in the pathogenesis of HLA and blood group-linked diseases.
摘要
交叉耐受假说认为，与某些微生物共享抗原的动物在感染初期会产生低水平抗体，而在后期会产生高水平抗体。在用抗原铁蛋白反复免疫后，已对高反应性的B10.M和B10.D2小鼠、低反应性的C3H和A.Thy-1.1小鼠，以及F1杂种（B10.M×A.Thy-1.1）和（B10.M×C3H/He）的抗体反应进行了测量，总共涉及483只小鼠。发现免疫反应发生了倒置，并且在风湿热中也描述了类似的延迟高抗体反应。有人提出免疫倒置机制可能在HLA和血型相关疾病的发病机制中起作用。
相似文献
1
Immune response inversion after hyperimmunisation. Possible mechanism in the pathogenesis of HLA-linked diseases.超免疫后免疫反应倒置。HLA相关疾病发病机制中的可能机制。
Ann Rheum Dis. 1978 Apr;37(2):152-8. doi: 10.1136/ard.37.2.152.
2
Cross-reactivity with mouse antigens in the ferritin immunogenetic (IR-gene) system.铁蛋白免疫遗传（IR基因）系统中与小鼠抗原的交叉反应性。
Br J Exp Pathol. 1978 Dec;59(6):644-51.
3
4
Naturally occurring leukemia viruses in H-2 congenic C57BL mice. II. Antibody response to viral envelope antigens.H-2 同源 C57BL 小鼠中的自然发生白血病病毒。II. 对病毒包膜抗原的抗体反应。
J Natl Cancer Inst. 1980 May;64(5):1191-8.
5
Effect of age on antibody responses in low responder C57BL/10ScSn and high responder A/J strains of mice.年龄对低反应性C57BL/10ScSn小鼠品系和高反应性A/J小鼠品系抗体反应的影响。
Mech Ageing Dev. 1993 Oct 1;71(1-2):131-41. doi: 10.1016/0047-6374(93)90041-o.
6
Genetic controls of T cell-independent Thy-1 alloantibody responses.非T细胞依赖性Thy-1同种抗体反应的遗传控制。
Immunogenetics. 1984;20(3):331-40. doi: 10.1007/BF00364214.
7
CD3- bone marrow cells augment the generation of cytotoxic T lymphocytes showing a preference for the X-chromosome linked gene product of stimulator cells.CD3阴性骨髓细胞增强细胞毒性T淋巴细胞的生成，这些细胞毒性T淋巴细胞对刺激细胞的X染色体连锁基因产物表现出偏好。
Microbiol Immunol. 2001;45(8):591-604. doi: 10.1111/j.1348-0421.2001.tb01290.x.
8
Genetic regulation of the antibody response to H-2Db alloantigens in mice. II. Tolerance to non-H-2 determinants abolishes the antibody response to H-2Db in B10.A(5R) mice.小鼠对H-2Db同种异体抗原抗体反应的遗传调控。II. 对非H-2决定簇的耐受性消除了B10.A(5R)小鼠对H-2Db的抗体反应。
J Exp Med. 1976 Jul 1;144(1):266-71. doi: 10.1084/jem.144.1.266.
9
10
[Flagellar antigen of Salmonella (author's transl) ].[沙门氏菌鞭毛抗原（作者译）]
Tanpakushitsu Kakusan Koso. 1974 Sep 17;19(10):783-93.
引用本文的文献
1
Adjuvant effect of dendritic cells activator Imiquimod in genetic immunization with HIV-1 p55 Gag.树突状细胞激活剂咪喹莫特在HIV-1 p55 Gag基因免疫中的佐剂作用。
J Immunol Tech Infect Dis. 2023;12(1). Epub 2023 Jan 10.
2
C-reactive protein, ESR, and klebsiella in ankylosing spondylitis.强直性脊柱炎中的C反应蛋白、红细胞沉降率和克雷伯菌
Ann Rheum Dis. 1980 Feb;39(1):45-9. doi: 10.1136/ard.39.1.45.
3
Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease.强直性脊柱炎患者与对照组中粪便产气克雷伯菌的频率与疾病个体特征的关系。
Ann Rheum Dis. 1980 Apr;39(2):118-23. doi: 10.1136/ard.39.2.118.
4
Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera.强直性脊柱炎、HLA - B27与克雷伯菌。I. 用兔抗血清进行的交叉反应研究。
Br J Exp Pathol. 1980 Feb;61(1):85-91.
5
6
A reinvestigation of the cross-reactivity between Klebsiella and HLA-B27 in the aetiology of ankylosing spondylitis.对克雷伯菌与人类白细胞抗原B27在强直性脊柱炎病因学中的交叉反应性的重新研究。
Clin Exp Immunol. 1985 Dec;62(3):662-71.
7
Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.强直性脊柱炎的系列研究。肺炎克雷伯菌与活动性疾病的关联。
Ann Rheum Dis. 1978 Apr;37(2):146-51. doi: 10.1136/ard.37.2.146.
本文引用的文献
1
DEPENDENCE OF ANTIBODY RESPONSES ON STRUCTURE AND POLYMORPHISM OF AUTOLOGOUS MACROMOLECULES.抗体反应对自身大分子结构和多态性的依赖性
Br Med Bull. 1963 Sep;19:219-24. doi: 10.1093/oxfordjournals.bmb.a070060.
2
The antibody responses of rabbits and rats to hemocyanin.兔子和大鼠对血蓝蛋白的抗体反应。
J Immunol. 1966 Sep;97(3):350-5.
3
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice.近交系小鼠中抗链球菌碳水化合物抗体的独特型同一性
Eur J Immunol. 1972 Aug;2(4):301-7. doi: 10.1002/eji.1830020402.
4
Variations in the responses of C57BL-10J and A-J mice to sheep red blood cells.C57BL - 10J小鼠和A - J小鼠对绵羊红细胞反应的差异。
J Exp Med. 1972 Nov 1;136(5):1063-71. doi: 10.1084/jem.136.5.1063.
5
Antigen binding and capping by lymphocytes of genetic nonresponder mice.遗传性无反应小鼠淋巴细胞的抗原结合与帽形成
J Exp Med. 1972 Aug 1;136(2):403-8. doi: 10.1084/jem.136.2.403.
6
Blood groups and their secretion in rheumatic fever.风湿热中的血型及其分泌情况。
Rheumatology. 1969;2:113-30.
7
The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism.小鼠的H-2基因座：关于其比较遗传学和多态性的观察与推测。
Folia Biol (Praha). 1968;14(5):335-58.
8
High association of an HL-A antigen, W27, with ankylosing spondylitis.HL - A抗原W27与强直性脊柱炎高度相关。
N Engl J Med. 1973 Apr 5;288(14):704-6. doi: 10.1056/NEJM197304052881403.
9
HL-A, immune-response genes, and disease.人类白细胞抗原、免疫反应基因与疾病
Lancet. 1974 Jun 22;1(7869):1269-75. doi: 10.1016/s0140-6736(74)90021-x.
10
Ankylosing spondylitis and HL-A 27.强直性脊柱炎与人类白细胞抗原27
Lancet. 1973 Apr 28;1(7809):904-7. doi: 10.1016/s0140-6736(73)91360-3.
Zotero 插件