超免疫后免疫反应倒置。HLA相关疾病发病机制中的可能机制。
Immune response inversion after hyperimmunisation. Possible mechanism in the pathogenesis of HLA-linked diseases.
作者信息
Young C R, Ebringer A, Archer J R
出版信息
Ann Rheum Dis. 1978 Apr;37(2):152-8. doi: 10.1136/ard.37.2.152.
Abstract
The crosstolerance hypothesis suggests that animals sharing antigens with some microorganisms will produce low antibody levels in the early part and high levels in the latter part of an infection. Antibody responses have been measured in high responder B10.M and B10.D2 mice and low responder C3H and A.Thy-1.1, as well as F1 hybrids (B10.M X A.Thy-1.1) and (B10.M X C3H/He), after repeated immunisation with the antigen ferritin, involving altogether 483 mice. An inversion in the immune response was found to occur and similar delayed high antibody responses have been described in rheumatic fever. It is suggested a mechanism of immune inversion may operate in the pathogenesis of HLA and blood group-linked diseases.
摘要
交叉耐受假说认为，与某些微生物共享抗原的动物在感染初期会产生低水平抗体，而在后期会产生高水平抗体。在用抗原铁蛋白反复免疫后，已对高反应性的B10.M和B10.D2小鼠、低反应性的C3H和A.Thy-1.1小鼠，以及F1杂种（B10.M×A.Thy-1.1）和（B10.M×C3H/He）的抗体反应进行了测量，总共涉及483只小鼠。发现免疫反应发生了倒置，并且在风湿热中也描述了类似的延迟高抗体反应。有人提出免疫倒置机制可能在HLA和血型相关疾病的发病机制中起作用。
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