6-甲氧基-四氢-β-咔啉与褪黑素在人视网膜中的情况

6-Methoxy-tetrahydro-beta-carboline and melatonin in the human retina.

作者信息

Leino M

出版信息

Exp Eye Res. 1984 Mar;38(3):325-30. doi: 10.1016/0014-4835(84)90170-2.

Abstract

The presence of two 5-methoxyindoles, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO- THBC ) and melatonin was demonstrated in human retinae using a highly specific gas chromatographic mass spectrometric method from eyes affected with various ocular diseases. Both compounds were found to occur in similar quantities. 6-MeO- THBC is a newly-identified endogenously-occurring retinal compound possibly acting as a neuromodulator. The importance of 6-MeO- THBC and other beta-carbolines especially compared to other 5-methoxyindoles is discussed.

摘要

采用高特异性气相色谱 - 质谱法，在患有各种眼部疾病的人视网膜中证实了两种5 - 甲氧基吲哚、6 - 甲氧基 - 1,2,3,4 - 四氢 - β - 咔啉（6 - MeO - THBC）和褪黑素的存在。发现这两种化合物的含量相似。6 - MeO - THBC是一种新鉴定出的内源性视网膜化合物，可能作为一种神经调节剂发挥作用。本文讨论了6 - MeO - THBC和其他β - 咔啉的重要性，特别是与其他5 - 甲氧基吲哚相比。