Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Pan Am Clinic Foundation, 75 Poseidon Bay, Winnipeg, MB R3M 3E4, Canada.
Nutrients. 2022 Jan 27;14(3):544. doi: 10.3390/nu14030544.
It is well established that creatine supplementation, primarily when combined with resistance training, significantly increases measures of muscle mass and performance (primarily strength). Emerging research also indicates that creatine supplementation may have favorable effects on measures of bone biology. These anabolic adaptations may be related to creatine influencing cellular hydration status, high-energy phosphate metabolism, growth factors, muscle protein kinetics, and the bone remodeling process. Accumulating research also suggests that creatine supplementation has anti-inflammatory and anti-catabolic properties, which may help create a favorable environment for muscle and bone accretion and recovery from exercise. Creatine supplementation has the ability to decrease markers of inflammation and possibly attenuate cancerous tumor growth progression. From a musculoskeletal perspective, there is some evidence to show that creatine supplementation reduces measures of muscle protein catabolism (primarily in males) and bone resorption when combined with resistance training. The purpose of this brief review is to summarize the current body of literature examining the potential anti-inflammatory and anti-catabolic effects of creatine supplementation across various research populations.
已证实，肌酸补充剂（主要与抗阻训练联合使用时）可显著增加肌肉质量和运动表现（主要是力量）的相关指标。新兴研究还表明，肌酸补充剂可能对骨骼生物学的相关指标具有有利影响。这些合成代谢适应性可能与肌酸影响细胞水合状态、高能磷酸代谢、生长因子、肌肉蛋白动力学和骨骼重塑过程有关。越来越多的研究还表明，肌酸补充剂具有抗炎和抗分解代谢特性，这可能有助于为肌肉和骨骼的积累以及运动后的恢复创造有利环境。肌酸补充剂有能力降低炎症标志物的水平，并可能抑制癌性肿瘤的生长进展。从肌肉骨骼的角度来看，有一些证据表明，肌酸补充剂与抗阻训练联合使用时，可降低肌肉蛋白分解代谢（主要在男性中）和骨吸收的相关指标。本文简要综述了目前关于肌酸补充剂对各种研究人群的潜在抗炎和抗分解代谢作用的文献。
