Shalev O, Eaton J W, Ben-Ishay D
Clin Exp Hypertens A. 1984;6(7):1367-77. doi: 10.3109/10641968409039603.
We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects.
我们评估了38例原发性高血压患者和37例健康对照者红细胞（RBC）对22Na+的摄取情况。所有受试者均为男性、白人、非肥胖且肾功能正常，排除了已知会影响RBC对Na+处理的性别、种族、激素、体重和肾脏因素。患者的平均±标准误22Na+摄取量为284±16微摩尔/升RBC/小时，而正常对照者为249±11微摩尔/升RBC/小时；尽管差异达到临界显著性，但个体值显示出相当大的重叠。因此，在我们的人群中，RBC对22Na+的摄取不是原发性高血压的可靠标志物。我们认为，应根据患者特征重新评估以往的研究，未来的研究在选择受试者时应采用严格的标准。
