确诊为原发性高血压的先证者的血压正常的亲属中，22Na+的全身及细胞（红细胞）转换异常。

Abnormal whole-body and cellular (erythrocytes) turnover of 22Na+ in normotensive relatives of probands with established essential hypertension.

Henningsen N C, Mattsson S, Nosslin B, Nelson D, Ohlsson O

Clin Sci (Lond). 1979 Dec;57 Suppl 5:321s-324s. doi: 10.1042/cs057321s.

Abstract

Whole-body elimination rate of 22Na+ was decreased in normotensive or borderline first-degree relatives of hypertensive probands. 2. Whole-body potassium, exchangeable sodium and urine excretion of sodium, potassium and creatinine were similar in relatives and controls. 3. Erythrocyte net influx of 22Na+ was significantly increased in normotensive relatives. 4. Abnormal whole-body and cellular handling of sodium (22Na+) demonstrated in relatives indicates that this abnormality may have an important role in the development of essential hypertension in man.

摘要

高血压先证者的血压正常或临界一级亲属中，22Na+的全身清除率降低。2. 亲属和对照组的全身钾、可交换钠以及钠、钾和肌酐的尿排泄量相似。3. 血压正常的亲属中，22Na+的红细胞净内流显著增加。4. 亲属中显示的钠（22Na+）全身及细胞处理异常表明，这种异常可能在人类原发性高血压的发生中起重要作用。