Schattner A, Merlin G, Bregman V, Hahn T, Levin S, Revel M, Wallach D
Clin Exp Immunol. 1984 Aug;57(2):265-70.
The interferon (IFN)-induced enzyme 2-5A synthetase was found in human peripheral blood polymorphonuclear cells (PMNL). The average enzyme activity in a group of 15 patients with various viral infections was significantly higher (25-fold) than in healthy individuals. Eight patients with multiple sclerosis and six patients with bacterial infections were found to have normal 2-5A synthetase levels in the PMNL. Relationship of PMNL 2-5A synthetase levels to IFN was confirmed by finding enzyme increases in PMNL incubated in vitro with IFN, as well as in patients undergoing IFN therapy. These findings suggest that in PMNL, as in other cells, the level of 2-5A synthetase can be regulated by IFN and can be increased as a result of IFN information in diseases.
在人外周血多形核细胞（PMNL）中发现了干扰素（IFN）诱导酶2-5A合成酶。一组15例患有各种病毒感染的患者的平均酶活性明显高于健康个体（25倍）。发现8例多发性硬化症患者和6例细菌感染患者的PMNL中2-5A合成酶水平正常。通过体外与IFN孵育的PMNL中酶增加以及接受IFN治疗的患者中酶增加，证实了PMNL 2-5A合成酶水平与IFN的关系。这些发现表明，在PMNL中，与其他细胞一样，2-5A合成酶的水平可受到IFN的调节，并可因疾病中的IFN信息而增加。
