人类甲醛脱氢酶（FDH）及其在4号染色体上的定位。

Human formaldehyde dehydrogenase (FDH) and its assignment to chromosome 4.

作者信息

Meera Khan P, Wijnen L M, Hagemeijer A, Pearson P L

出版信息

Cytogenet Cell Genet. 1984;38(2):112-5. doi: 10.1159/000132041.

DOI:10.1159/000132041

Abstract

A Cellogel procedure for electrophoretic characterization of formaldehyde dehydrogenase (FDH) is described. Isozyme profiles in 24 different human tissues indicate extreme quantitative heterogeneity and the existence of one major form and at least two minor forms of FDH in man. Biochemical and genetic analysis of the enzyme in Chinese hamster-human somatic cell hybrids has shown that the functional molecule of FDH is probably composed of two identical subunits and that its structural locus may be assigned to human chromosome 4.

摘要

本文描述了一种用于甲醛脱氢酶（FDH）电泳表征的Cellogel程序。24种不同人体组织中的同工酶谱表明，人源FDH存在极端的定量异质性，且存在一种主要形式和至少两种次要形式。对中国仓鼠-人体细胞杂种中该酶的生化和遗传分析表明，FDH的功能分子可能由两个相同的亚基组成，其结构基因座可能位于人类4号染色体上。

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