宿主防御小鼠肺炎病原体（鼠沙眼衣原体）中的抗体。
Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).
作者信息
Williams D M, Schachter J, Weiner M H, Grubbs B
出版信息
Infect Immun. 1984 Sep;45(3):674-8. doi: 10.1128/iai.45.3.674-678.1984.
Abstract
In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.
摘要
在使用鼠沙眼衣原体的衣原体肺炎小鼠模型中，经鼻给予免疫血清可延迟裸鼠（nu/nu）死亡，并防止nu/+小鼠死亡。血清来源的免疫球蛋白G和A组分以及含有免疫球蛋白G和A的免疫灌洗液组分在用于调理鼠沙眼衣原体接种物时可有效产生保护作用。在超清洁小鼠（先前无菌，然后接种对小鼠无致病性的有限菌群）中，静脉给予抗体无效。抗体和细胞介导免疫的非特异性刺激（先前感染荚膜组织胞浆菌后）在增强宿主对鼠沙眼衣原体的抵抗力方面具有相加作用。
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