肿瘤坏死因子α是由鼠沙眼衣原体感染诱导产生的一种细胞毒素。
Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection.
作者信息
Williams D M, Bonewald L F, Roodman G D, Byrne G I, Magee D M, Schachter J
机构信息
Department of Medicine, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas.
出版信息
Infect Immun. 1989 May;57(5):1351-5. doi: 10.1128/iai.57.5.1351-1355.1989.
Abstract
A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice (nu/+) produced tumor necrosis factor alpha in vitro in response to mouse pneumonitis agent antigen. The tumor necrosis factor alpha measured in these supernatants by immunoassay was shown to have bioactivity in a cytotoxic assay in which uninfected target cells were used. This cytotoxicity was distinct from the gamma interferon-related cytotoxicity against C. trachomatis-infected targets that we described previously.
摘要
利用由鼠沙眼衣原体（小鼠肺炎病原体）引起的肺炎小鼠模型，来证明无胸腺裸鼠（nu/nu）和杂合小鼠（nu/+）的全脾细胞在体外对小鼠肺炎病原体抗原产生肿瘤坏死因子α。通过免疫测定法在这些上清液中测得的肿瘤坏死因子α，在使用未感染靶细胞的细胞毒性试验中显示具有生物活性。这种细胞毒性不同于我们之前描述的针对沙眼衣原体感染靶标的γ干扰素相关细胞毒性。
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