自然杀伤细胞在小鼠肺炎病原体（鼠沙眼衣原体）感染中的作用。
Role of natural killer cells in infection with the mouse pneumonitis agent (murine Chlamydia trachomatis).
作者信息
Williams D M, Schachter J, Grubbs B
出版信息
Infect Immun. 1987 Jan;55(1):223-6. doi: 10.1128/iai.55.1.223-226.1987.
Abstract
Natural killer (NK) activity is increased in both spleen and lung early in pulmonary infection by murine Chlamydia trachomatis in both susceptible nude and resistant heterozygous (nu/+) mice. Ablation of the rise in NK activity by giving the mice antiasialo GM-1 antibody or stimulation of NK activity by immunomodulators did not affect quantitative tissue counts of the mouse pneumonitis biovar of C. trachomatis or significantly affect survival. Studies are needed to further define the role of NK cells in host defense, immunoregulation, and immunopathology during chlamydial infection.
摘要
在易感性裸鼠和抗性杂合子（nu/+）小鼠中，鼠沙眼衣原体肺部感染早期，脾脏和肺中的自然杀伤（NK）活性均会升高。给小鼠注射抗唾液酸GM-1抗体消除NK活性的升高，或用免疫调节剂刺激NK活性，均不影响沙眼衣原体小鼠肺炎生物变种的定量组织计数，也未显著影响存活率。需要开展研究以进一步明确NK细胞在衣原体感染期间宿主防御、免疫调节和免疫病理学中的作用。
相似文献
1
Role of natural killer cells in infection with the mouse pneumonitis agent (murine Chlamydia trachomatis).自然杀伤细胞在小鼠肺炎病原体（鼠沙眼衣原体）感染中的作用。
Infect Immun. 1987 Jan;55(1):223-6. doi: 10.1128/iai.55.1.223-226.1987.
2
Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).宿主防御小鼠肺炎病原体（鼠沙眼衣原体）中的抗体。
Infect Immun. 1984 Sep;45(3):674-8. doi: 10.1128/iai.45.3.674-678.1984.
3
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.小鼠沙眼衣原体肺炎期间的γ干扰素水平。
Infect Immun. 1993 Aug;61(8):3556-8. doi: 10.1128/iai.61.8.3556-3558.1993.
4
Cellular immunity to the mouse pneumonitis agent.
J Infect Dis. 1984 Apr;149(4):630-9. doi: 10.1093/infdis/149.4.630.
5
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.鼠沙眼衣原体继发感染中的体液免疫和细胞免疫。
Infect Immun. 1997 Jul;65(7):2876-82. doi: 10.1128/iai.65.7.2876-2882.1997.
6
Chlamydia trachomatis pneumonia in the severe combined immunodeficiency (SCID) mouse.重度联合免疫缺陷（SCID）小鼠中的沙眼衣原体肺炎
Reg Immunol. 1993 Nov-Dec;5(6):305-11.
7
Role of cell-mediated immunity in chlamydial infection: implications for ocular immunity.细胞介导免疫在衣原体感染中的作用：对眼部免疫的影响
Rev Infect Dis. 1985 Nov-Dec;7(6):754-9. doi: 10.1093/clinids/7.6.754.
8
Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse.免疫功能低下（裸）小鼠的沙眼衣原体肺炎
J Infect Dis. 1981 Feb;143(2):238-41. doi: 10.1093/infdis/143.2.238.
9
10
Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection.肿瘤坏死因子α是由鼠沙眼衣原体感染诱导产生的一种细胞毒素。
Infect Immun. 1989 May;57(5):1351-5. doi: 10.1128/iai.57.5.1351-1355.1989.
引用本文的文献
1
Innate Lymphoid Cells Are Required for Endometrial Resistance to Infection.先天淋巴细胞对于子宫内膜抗感染的抵抗是必需的。
Infect Immun. 2020 Jun 22;88(7). doi: 10.1128/IAI.00152-20.
2
Evasion of Innate Lymphoid Cell-Regulated Gamma Interferon Responses by Chlamydia muridarum To Achieve Long-Lasting Colonization in Mouse Colon.鼠型沙眼衣原体逃避固有淋巴细胞调控的γ干扰素应答，从而在小鼠结肠中实现持久定植。
Infect Immun. 2020 Feb 20;88(3). doi: 10.1128/IAI.00798-19.
3
Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.自然杀伤细胞调节衣原体肺部感染中的Th1/Treg和Th17/Treg平衡。
J Cell Mol Med. 2016 Jul;20(7):1339-51. doi: 10.1111/jcmm.12821. Epub 2016 Mar 29.
4
T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.T淋巴细胞免疫在宿主抵御沙眼衣原体中的作用及其对疫苗研发的意义。
Can J Infect Dis. 1998 Mar;9(2):99-108. doi: 10.1155/1998/395297.
5
Role of NK cells in early host response to chlamydial genital infection.自然杀伤细胞在宿主对衣原体性生殖器感染早期反应中的作用。
Infect Immun. 1998 Dec;66(12):5867-75. doi: 10.1128/IAI.66.12.5867-5875.1998.
6
A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection.白细胞介素-6在宿主抵御小鼠沙眼衣原体感染中的作用。
Infect Immun. 1998 Sep;66(9):4564-7. doi: 10.1128/IAI.66.9.4564-4567.1998.
7
B-cell-deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis.B细胞缺陷型小鼠对沙眼衣原体生殖道感染产生完全的免疫保护。
Immunology. 1997 Dec;92(4):422-8. doi: 10.1046/j.1365-2567.1997.00378.x.
8
Characterization of B-cell responses to Chlamydia trachomatis antigens in humans with trachoma.沙眼患者中B细胞对沙眼衣原体抗原反应的特征分析
Infect Immun. 1997 Dec;65(12):4958-64. doi: 10.1128/iai.65.12.4958-4964.1997.
9
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.鼠沙眼衣原体继发感染中的体液免疫和细胞免疫。
Infect Immun. 1997 Jul;65(7):2876-82. doi: 10.1128/iai.65.7.2876-2882.1997.
10
Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response.尽管存在强烈的局部免疫球蛋白A反应，但沙眼衣原体生殖道感染在γ干扰素受体缺陷小鼠中未能诱导保护性免疫。
Infect Immun. 1997 Mar;65(3):1032-44. doi: 10.1128/IAI.65.3.1032-1044.1997.
本文引用的文献
1
Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse.免疫功能低下（裸）小鼠的沙眼衣原体肺炎
J Infect Dis. 1981 Feb;143(2):238-41. doi: 10.1093/infdis/143.2.238.
2
Cytotoxic cells induced after Chlamydia psittaci infection in mice.鹦鹉热衣原体感染小鼠后诱导产生的细胞毒性细胞。
Infect Immun. 1982 Mar;35(3):1011-7. doi: 10.1128/iai.35.3.1011-1017.1982.
3
Natural killer cells induced by acute and chronic toxoplasma infection.急性和慢性弓形虫感染诱导的自然杀伤细胞。
Cell Immunol. 1982 May 15;69(2):330-46. doi: 10.1016/0008-8749(82)90076-4.
4
Failure to detect cell-mediated cytotoxicity against Chlamydia trachomatis-infected cells.未能检测到针对沙眼衣原体感染细胞的细胞介导细胞毒性。
Infect Immun. 1983 Mar;39(3):1271-4. doi: 10.1128/iai.39.3.1271-1274.1983.
5
Lack of cell-mediated cytotoxicity towards Chlamydia trachomatis infected target cells in humans.
Acta Pathol Microbiol Immunol Scand C. 1984 Jun;92(3):153-9. doi: 10.1111/j.1699-0463.1984.tb00067.x.
6
7
Cellular immunity to the mouse pneumonitis agent.
J Infect Dis. 1984 Apr;149(4):630-9. doi: 10.1093/infdis/149.4.630.
8
Suppressive effect of human natural killer cells on pokeweed mitogen-induced B cell differentiation.人自然杀伤细胞对商陆丝裂原诱导的B细胞分化的抑制作用。
J Immunol. 1983 Aug;131(2):651-7.
9
Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses.人类自然杀伤细胞在暴露于流感病毒和疱疹病毒时通过产生干扰素对细胞毒性进行正向自我调节。
J Exp Med. 1982 Oct 1;156(4):1222-34. doi: 10.1084/jem.156.4.1222.
10
In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans.自然杀伤（NK）细胞对新型隐球菌的体外反应性。
J Immunol. 1982 Apr;128(4):1577-83.
Zotero 插件