伯纳特柯克斯体诱导小鼠对内毒素产生高反应性
Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii.
作者信息
Schramek S, Kazar J, Sekeyova Z, Freudenberg M A, Galanos C
出版信息
Infect Immun. 1984 Sep;45(3):713-7. doi: 10.1128/iai.45.3.713-717.1984.
Abstract
Intraperitoneal inoculation of mice with live or killed Coxiella burnetii phase I or phase II cells induced a marked hyperreactivity to the lethal effect of bacterial endotoxin and was accompanied by a marked hepatosplenomegaly. The degree and duration of hyperreactivity depended on the dose of C. burnetii administered and were higher with phase I than with phase II cells. Sensitization to the lethal effects of endotoxin and induction of splenomegaly by phase I C. burnetii cells also proceeded in the endotoxin-resistant C3H/HeJ strain of mice. Preincubation of C. burnetii cells with the corresponding immune serum significantly diminished the ability of phase I but not phase II cells to induce hyperreactivity to endotoxin.
摘要
用活的或灭活的伯纳特立克次体Ⅰ相或Ⅱ相细胞对小鼠进行腹腔接种，可诱导其对细菌内毒素的致死作用产生明显的高反应性，并伴有明显的肝脾肿大。高反应性的程度和持续时间取决于所给予的伯纳特立克次体剂量，Ⅰ相细胞诱导的高反应性程度和持续时间高于Ⅱ相细胞。Ⅰ相伯纳特立克次体细胞对内毒素致死作用的致敏以及脾肿大的诱导在对内毒素有抗性的C3H/HeJ小鼠品系中也会发生。将伯纳特立克次体细胞与相应的免疫血清预孵育，可显著降低Ⅰ相细胞而非Ⅱ相细胞诱导对内毒素高反应性的能力。
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