Humphres R C, Hinrichs D J
Infect Immun. 1981 Feb;31(2):641-5. doi: 10.1128/iai.31.2.641-645.1981.
BALB/c mice infected with Coxiella burnetii phase I developed a state of acquired resistance which could be detected during week 2 postinfection. Immune serum, administered to normal mice 24 h before challenge with C. burnetii, appeared to accelerate the development of resistance. An increased clearance rate could be measured in these serum recipients 1 week postinfection. Simultaneous administration of immune serum and C. burnetii did not affect the normal clearance rate of rickettsiae from the spleens of infected mice during week 1, but enhanced clearance of the organism by 14 days postchallenge. Passive transfer of immune serum 24 h after challenge of normal mice with viable C. burnetii had no effect on rickettsial growth within the spleens of animals treated in this fashion. Treatment of athymic mice with immune serum 24 h before challenge with C. burnetii had no effect on rickettsial multiplication within the spleens of these T-cell-deficient animals.
感染了第一相伯纳特柯克斯体的BALB/c小鼠产生了一种获得性抗性状态，这种状态在感染后第2周即可检测到。在用伯纳特柯克斯体攻击正常小鼠前24小时给其注射免疫血清，似乎能加速抗性的发展。在这些接受血清的小鼠感染后1周可检测到清除率增加。在感染第1周，同时注射免疫血清和伯纳特柯克斯体并不影响感染小鼠脾脏中立克次体的正常清除率，但在攻击后14天可增强对该病原体的清除。在用活的伯纳特柯克斯体攻击正常小鼠24小时后被动转移免疫血清，对以这种方式处理的动物脾脏中的立克次体生长没有影响。在用伯纳特柯克斯体攻击无胸腺小鼠前24小时用免疫血清处理，对这些T细胞缺陷动物脾脏中的立克次体增殖没有影响。
