胃癌患者腹腔游离癌细胞的预后意义
Prognostic significance of intraperitoneal free cancer cells in gastric cancer patients.
作者信息
Koga S, Kaibara N, Iitsuka Y, Kudo H, Kimura A, Hiraoka H
出版信息
J Cancer Res Clin Oncol. 1984;108(2):236-8. doi: 10.1007/BF00402474.
Abstract
We performed intraoperative peritoneal cytology in 171 gastric cancer patients undergoing curative surgery. Intraperitoneal free cancer cells were demonstrated in almost all patients in whom the area of serosal cancer invasion exceeded 15-20 cm2. In patients with both serosal cancer invasion and free cancer cells the 5-year survival rat was 13% as compared with 85% for patients who had neither, and 40% for patients who had serosal invasion but no free peritoneal cancer cells. Peritoneal metastasis was the most frequently observed recurrence pattern. Therefore, in gastric cancer patients with marked serosal invasion, intraoperative IP administration of cytocidal anticancer drugs should be considered.
摘要
我们对171例行根治性手术的胃癌患者进行了术中腹腔细胞学检查。几乎所有浆膜癌浸润面积超过15 - 20平方厘米的患者腹腔内均发现游离癌细胞。既有浆膜癌浸润又有游离癌细胞的患者5年生存率为13%，相比之下，既无浆膜癌浸润又无游离癌细胞的患者5年生存率为85%，有浆膜浸润但无腹腔游离癌细胞的患者5年生存率为40%。腹膜转移是最常见的复发模式。因此，对于浆膜浸润明显的胃癌患者，应考虑术中腹腔内给予细胞毒性抗癌药物。
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