Mantle P G, Laws I, Tan M J, Tizard M
J Gen Microbiol. 1984 May;130(5):1293-8. doi: 10.1099/00221287-130-5-1293.
A strain of Penicillium nigricans, which produces both the antifungal antibiotic griseofulvin and tremorgenic penitrem mycotoxins concurrently in static liquid culture, also elaborated both metabolites in submerged culture when stimulated by calcium chloride to sporulate. Maximum yield of penitrems (60 mg l-1) occurred within 5 d in a 60 l stirred fermenter, thus constituting the first significant process for penitrem production in submerged culture.
一株黑曲霉在静置液体培养中能同时产生抗真菌抗生素灰黄霉素和震颤性青霉震颤毒素，在氯化钙刺激产孢时，其在深层培养中也能产生这两种代谢产物。在60升搅拌发酵罐中，5天内青霉震颤毒素的产量最高可达60毫克/升，这是深层培养中首次大规模生产青霉震颤毒素的重要工艺。
