Dreosti I E, McMichael A J, Bridle T M
Med J Aust. 1984 Sep 29;141(7):409-11.
Experimental studies in pregnant rats failed to demonstrate the presence of a teratogenic agent in water from the Mount Gambier Blue Lake or from several local bores, even when the water from each of those two sources was concentrated tenfold and fivefold, respectively, by freeze drying. The experimental data thus failed to corroborate the previously reported epidemiological evidence of an increased risk of human teratogenesis in pregnant women who were drinking water from these sources. The growth of rat embryos in culture on serum taken from pregnant women in the Mount Gambier region was identical, regardless of the source of drinking water consumed by the individual donors. The findings do not suggest the presence of a teratogen in Mount Gambier water supplies; however, they should be regarded with the caution which is necessarily associated with teratology studies conducted across the boundaries of species.
对怀孕大鼠的实验研究未能证明甘比尔山蓝湖或当地几口井水中存在致畸剂，即使将这两个水源的水分别通过冷冻干燥浓缩了10倍和5倍。因此，实验数据未能证实先前报道的流行病学证据，即饮用这些水源水的孕妇出现人类致畸风险增加。无论个体供体饮用的水源如何，在取自甘比尔山地区孕妇血清中培养的大鼠胚胎生长情况相同。这些发现并不表明甘比尔山供水系统中存在致畸剂；然而，对于跨物种进行的致畸学研究必然要持谨慎态度。
