Taha S A, Dost S M, Sedrani S H
Pediatr Res. 1984 Aug;18(8):739-41. doi: 10.1203/00006450-198408000-00013.
Venous blood was obtained from 100 consecutive and unselected Saudi Arabian mothers and their neonates within 48 h after delivery. Plasma levels of 25-hydroxyvitamin D (25-OHD) and total calcium were measured in paired samples. Fifty-nine mothers and 70 neonates had subnormal (less than 10 ng/ml) 25-OHD levels. Plasma Ca concentrations were low in 61% of the mothers and 59% of the newborns consisting of 10 preterm and 38 full term babies. There were significant correlation between the plasma levels of maternal and neonatal 25-OHD (r = 0.54; P = 0.0001), maternal 25-OHD and Ca (r = -0.22; P = 0.03), neonatal 25-OHD and Ca (r = -0.28; P = 0.0009), and maternal and neonatal calcium levels (r = 0.46; P = 0.0001). Nevertheless, maternal 25-OHD was not invariably higher than that in the infant. Normocalcemia was observed in 29 neonates and 26 mothers (20 mother/baby pairs) in the presence of subnormal maternal 25-OHD. Twenty babies and 16 mothers including nine mother/baby pairs had hypocalcemia in the presence of normal levels of 25-OHD. This indicates that vitamin D plays a crucial, but not exclusive, role in calcium homeostasis during pregnancy. This study revealed that vitamin D deficiency is very prevalent during pregnancy in Saudi Arabia. It also showed that asymptomatic hypocalcemia in full term babies is far commoner than is generally appreciated. It is considered that vitamin D deficiency is primarily due to lack of exposure to sunlight. Encouragement to obtain sunlight exposure and fortification of food are the only alternative measures.
在分娩后48小时内，从100名连续且未经筛选的沙特阿拉伯母亲及其新生儿身上采集静脉血。对配对样本测量25-羟维生素D（25-OHD）和总钙的血浆水平。59名母亲和70名新生儿的25-OHD水平低于正常（低于10 ng/ml）。61%的母亲和59%的新生儿血浆钙浓度较低，其中包括10名早产儿和38名足月儿。母亲和新生儿的25-OHD血浆水平之间存在显著相关性（r = 0.54；P = 0.0001），母亲的25-OHD与钙之间存在显著相关性（r = -0.22；P = 0.03），新生儿的25-OHD与钙之间存在显著相关性（r = -0.28；P = 0.0009），母亲和新生儿的钙水平之间存在显著相关性（r = 0.46；P = 0.0001）。然而，母亲的25-OHD并不总是高于婴儿的。在母亲25-OHD低于正常水平的情况下，29名新生儿和26名母亲（20对母婴）出现了正常血钙。在25-OHD水平正常的情况下，20名婴儿和16名母亲（包括9对母婴）出现了低钙血症。这表明维生素D在孕期钙稳态中起关键但非唯一作用。这项研究表明，沙特阿拉伯孕期维生素D缺乏非常普遍。研究还表明，足月儿无症状性低钙血症远比普遍认为的更为常见。认为维生素D缺乏主要是由于缺乏阳光照射。鼓励晒太阳和食物强化是仅有的替代措施。
