Poliakov L M, Panin L E, Voĭtsekhovskaia E E
Probl Endokrinol (Mosk). 1984 Jul-Aug;30(4):60-3.
Intravenous injections of the blood plasma iodinated lipoproteins (LP) to rats led to the marker binding and penetration into the adrenal cells. The most intensive absorption was specific to LPs of high density (LPHD) and, to a lesser degree, to LPs of low and very low density (LPLD, LPVLD). Intensive exercises produced an enhanced LPHD accumulation and a reduced LPLD level in the adrenal tissues. During subcellular fractionation of the adrenals LPVLDs were uniformly distributed among cellular organelles, LPLDs were accumulated in lysosomes and cytosol, whereas a large LPHD amount was collected in the small cytoplasmic membranes. The exercises led to an increase in LPHD binding with the fraction of small cytoplasmic membranes. The role of different LP classes in steroidogenesis processes is discussed. The differences, found in the absorption extent and localization of LP labelled, allowed one to suggest that the pathways of intracellular metabolism of several LP classes in the rat adrenals are distinctive.
给大鼠静脉注射血浆碘化脂蛋白（LP）会导致标记物与肾上腺细胞结合并渗透进去。吸收最为强烈的是高密度脂蛋白（LPHD），低密度和极低密度脂蛋白（LPLD、LPVLD）的吸收程度则相对较小。高强度运动使肾上腺组织中LPHD的积累增加，LPLD水平降低。在肾上腺的亚细胞分级分离过程中，LPVLD均匀分布于细胞器之间，LPLD积累于溶酶体和细胞质中，而大量LPHD则聚集在小细胞质膜中。运动导致LPHD与小细胞质膜部分的结合增加。文中讨论了不同类别LP在类固醇生成过程中的作用。所发现的标记LP吸收程度和定位的差异表明，大鼠肾上腺中几种LP类别的细胞内代谢途径是不同的。
