Danis V A, Harries A D, Heatley R V
Scand J Gastroenterol. 1984 Jul;19(5):603-6.
One hundred and sixty patients have been studied to assess the significance of circulating antigen-antibody complexes in inflammatory bowel disease (IBD). Sera from patients with ulcerative colitis and Crohn's disease were assayed for Clq-binding antigen-antibody complexes (CIC) and the results compared with those obtained from 52 patients with other inflammatory gastrointestinal diseases (GI controls) and 26 normal volunteers (normal controls). Significantly elevated CIC levels were found in patients with active IBD compared with inactive IBD or normal controls. However, similar high levels were also found in the GI control group. CIC levels in a group of undernourished patients with Crohn's disease fell significantly after treatment with an oral nutritional supplement. The results suggest that CIC-mediated inflammation is likely to be associated with intestinal mucosal disease in a non-specific manner.
对160例患者进行了研究，以评估循环抗原-抗体复合物在炎症性肠病（IBD）中的意义。对溃疡性结肠炎和克罗恩病患者的血清进行了Clq结合抗原-抗体复合物（CIC）检测，并将结果与52例其他炎症性胃肠疾病患者（胃肠道疾病对照）和26名正常志愿者（正常对照）的结果进行了比较。与非活动期IBD患者或正常对照相比，活动期IBD患者的CIC水平显著升高。然而，在胃肠道疾病对照组中也发现了类似的高水平。一组营养不良的克罗恩病患者在口服营养补充剂治疗后，CIC水平显著下降。结果表明，CIC介导的炎症可能以非特异性方式与肠道黏膜疾病相关。
