葵子麝香的神经毒性特性。

Neurotoxic properties of musk ambrette.

作者信息

Spencer P S, Bischoff-Fenton M C, Moreno O M, Opdyke D L, Ford R A

出版信息

Toxicol Appl Pharmacol. 1984 Sep 30;75(3):571-5. doi: 10.1016/0041-008x(84)90194-7.

Abstract

Musk ambrette (2,6-dinitro-3-methoxy-4-tert-butyltoluene), a nitro-musk compound widely used as a fixative in fragrance formulations and found to a lesser degree in flavor compositions, produces hindlimb weakness when administered in the diet or applied to skin of rats for periods up to 12 weeks. Underlying neuropathologic changes consist of primary demyelination and distal axonal degeneration in selected regions of the central and peripheral nervous system. Murine neurological disease induced by musk ambrette occurs at doses well above estimated maximum daily human exposure. Lifetime experimental neurotoxicology studies using lower concentrations of musk ambrette for prolonged periods would be needed for the estimation of human risk.

摘要

葵子麝香（2,6 - 二硝基 - 3 - 甲氧基 - 4 - 叔丁基甲苯）是一种硝基麝香化合物，广泛用作香料配方中的定香剂，在调味组合物中的含量较低。当在饮食中给予或涂抹于大鼠皮肤长达12周时，它会导致后肢无力。潜在的神经病理变化包括中枢和周围神经系统特定区域的原发性脱髓鞘和远端轴突变性。葵子麝香诱发的小鼠神经疾病发生剂量远高于估计的人类每日最大暴露量。需要进行长期使用较低浓度葵子麝香的终身实验神经毒理学研究来评估人类风险。