Stenström G, Sjöström L, Smith U
Acta Endocrinol (Copenh). 1984 Aug;106(4):511-5. doi: 10.1530/acta.0.1060511.
Sixty patients undergoing operation for phaeochromocytoma were investigated in the pre- and postoperative states with respect to fasting blood glucose levels. When 6 previously known or suspected diabetics were excluded, preoperative diabetes (fasting blood glucose levels greater than or equal to 7.0 mmol/l) were found in 3 of 13 (23%) with sustained hypertension, in 6 of 12 (50%) with sustained hypertension associated with paroxysms and in 4 of 24 (17%) with paroxysmal hypertension. None of the 5 patients with atypical clinical symptoms had glucose levels greater than or equal to 7.0 mmol/l. In the groups of patients with particularly high urinary excretion of catecholamines and vanilmandelic acid higher blood glucose levels were also found. The postoperative blood glucose levels in the follow-up study were normal and less than 5.8 mmol/l in all cases except in 3 of the 4 still living patients with a previously known diabetes and in 1 patient with a malignant tumour. Thus, manifest diabetes, defined as fasting glucose levels greater than or equal to 7.0 mmol/l, is frequently present in patients with phaeochromocytoma (24% in the present study) and the diabetes is reversed by removal of the tumour.
对60例接受嗜铬细胞瘤手术的患者在术前和术后进行了空腹血糖水平调查。排除6例先前已知或疑似糖尿病患者后，在13例持续性高血压患者中有3例（23%）术前患有糖尿病（空腹血糖水平大于或等于7.0 mmol/l），在12例伴有阵发性发作的持续性高血压患者中有6例（50%），在24例阵发性高血压患者中有4例（17%）。5例具有非典型临床症状的患者中，无一例血糖水平大于或等于7.0 mmol/l。在儿茶酚胺和香草扁桃酸尿排泄量特别高的患者组中，也发现血糖水平较高。随访研究中，除4例仍存活的先前已知糖尿病患者中的3例以及1例恶性肿瘤患者外，所有患者术后血糖水平均正常且低于5.8 mmol/l。因此，定义为空腹血糖水平大于或等于7.0 mmol/l的显性糖尿病在嗜铬细胞瘤患者中很常见（本研究中为24%），并且通过切除肿瘤可使糖尿病得到逆转。
