Glueck C J, Gartside P, Laskarzewski P M, Khoury P, Tyroler H A
Am Heart J. 1984 Sep;108(3 Pt 2):815-26. doi: 10.1016/0002-8703(84)90677-x.
Black male and female juveniles and adult black males have higher levels of high-density lipoprotein (HDL) cholesterol than do whites, differences that potentially "protect" them against augmented coronary heart disease morbidity and mortality, given an excess of certain coronary heart disease risk factors among blacks, particularly hypertension. The loss of the "protective" HDL cholesterol difference in adult black females appears most likely to be due to their pandemic obesity. Inasmuch as blacks smoke more, are more likely to have diabetes, and are more often treated with antihypertensives, these factors would tend to reduce black-white differences in HDL cholesterol. Black-white differences in alcohol intake and habitual and leisure-time physical activity would not be likely, in the aggregate, to affect black-white differences in HDL cholesterol. It thus seems likely that, whereas environment has a substantial effect on HDL cholesterol for blacks and whites, there may be a "genetic" vector accounting for higher levels of HDL cholesterol in blacks.
黑人青少年男性和女性以及成年黑人男性的高密度脂蛋白（HDL）胆固醇水平高于白人。鉴于黑人中存在某些冠心病风险因素（尤其是高血压），这些差异可能会“保护”他们免受冠心病发病率和死亡率增加的影响。成年黑人女性中“保护性”HDL胆固醇差异的消失似乎最有可能是由于她们普遍肥胖。由于黑人吸烟更多、更易患糖尿病且更常接受抗高血压治疗，这些因素往往会缩小HDL胆固醇的黑白差异。总体而言，酒精摄入量以及习惯性和休闲性身体活动的黑白差异不太可能影响HDL胆固醇的黑白差异。因此，虽然环境对黑人和白人的HDL胆固醇有很大影响，但可能存在一种“遗传”因素导致黑人的HDL胆固醇水平较高。
