非洲裔和高加索裔孕妇脂质及脂蛋白代谢的种族差异。
Ethnic differences in lipid and lipoprotein metabolism in pregnant women of African and Caucasian origin.
作者信息
Koukkou E, Watts G F, Mazurkiewicz J, Lowy C
机构信息
Department of Endocrinology and Chemical Pathology, St Thomas's Hospital (UMDS), London.
出版信息
J Clin Pathol. 1994 Dec;47(12):1105-7. doi: 10.1136/jcp.47.12.1105.
AIMS
To investigate differences in serum lipid, lipoprotein and apolipoprotein concentrations in pregnant women of different ethnic origin.
METHODS
Serum lipid, lipoprotein and apolipoprotein concentrations were measured in 232 women (114 Caucasians, 118 Africans/Afro-Caribbeans), who presented consecutively for screening for gestational diabetes in the third trimester of pregnancy.
RESULTS
African/Afro-Caribbean pregnant women had lower serum concentrations of total cholesterol, low density lipoprotein cholesterol, triglycerides, and apolipoprotein B and higher high density lipoprotein cholesterol and Lp(a) lipoprotein concentrations compared with Caucasian women. Apolipoprotein A1 concentrations were similar in the two groups. The differences were not attributable to differences in weight, age, parity, or postload plasma glucose levels.
CONCLUSION
Ethnic origin is an important determinant of serum lipid, lipoprotein and apolipoprotein concentrations during pregnancy.
目的
研究不同种族孕妇血清脂质、脂蛋白和载脂蛋白浓度的差异。
方法
对232名在妊娠晚期连续前来筛查妊娠期糖尿病的女性（114名白种人、118名非洲人/非裔加勒比人）进行血清脂质、脂蛋白和载脂蛋白浓度测定。
结果
与白种女性相比，非洲/非裔加勒比孕妇的总胆固醇、低密度脂蛋白胆固醇、甘油三酯和载脂蛋白B血清浓度较低，而高密度脂蛋白胆固醇和Lp(a)脂蛋白浓度较高。两组的载脂蛋白A1浓度相似。这些差异并非由体重、年龄、产次或负荷后血糖水平的差异所致。
结论
种族是孕期血清脂质、脂蛋白和载脂蛋白浓度的重要决定因素。
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