Foster P, Jackson M
Renaissance Health Care Network, Drew Hamilton Clinic, Harlem Hospital Center Department of Ambulatory Care, New York, New York.
J Natl Med Assoc. 1993 Mar;85(3):211-5.
Lipoprotein phenotypes total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride levels were obtained from blood samples of 189 patients attending the Drew Hamilton Clinic in Central Harlem, New York, between 1987 and 1988. The study population ranged in age from 7 to 88 years; 135 of the patients were females and 54 were males. A difference in distribution of lipoprotein phenotypes was observed compared with the general population of the United States. Sixty-seven percent of blacks in this study were Type IIA compared with an estimated 10% of the general US population. Differences also were observed for blacks versus the general US population for Type IV (24% versus 45%), Type IIB (9% versus 40%), and Type V (0% versus 5%). Types I and III were rare in both groups (0% versus < 1%). The increased frequency of Type IIA among this predominantly black inner-city population may have implications for treatment strategies and prognostic value for predicting the risk of coronary heart disease.
脂蛋白表型、总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯水平的数据来自1987年至1988年间在纽约哈莱姆市中心区德鲁·汉密尔顿诊所就诊的189名患者的血液样本。研究人群年龄在7岁至88岁之间；其中135名患者为女性，54名患者为男性。与美国普通人群相比，观察到脂蛋白表型分布存在差异。本研究中67%的黑人属于IIA型，而美国普通人群中这一比例估计为10%。在IV型（24%对45%）、IIB型（9%对40%）和V型（0%对5%）方面，黑人与美国普通人群之间也存在差异。I型和III型在两组中都很罕见（0%对<1%）。在这个以黑人为主的市中心人群中，IIA型频率的增加可能对治疗策略以及预测冠心病风险的预后价值有影响。
