Botey J, Cozzo M, Marin A, Eseverri J L
Servicio de Alergia e Inmunologia Clínica, Hospital Infantil Valle de Hebron, Universidad Autonoma, Barcelona, Spain.
Allergol Immunopathol (Madr). 1988 Nov-Dec;16(6):425-8.
This study presents the cases of five children who consulted us because of skin pathology, in which a hypersensitivity to monosodium glutamate (MSG) was detected. In four children, the motive for consultation was urticaria; in two children, urticaria was accompanied by angioedema, while the fifth child presented with atopic dermatitis and urticaria. In the four cases of urticaria, the etiological diagnosis was probable drug allergy. The oral provocation test (OPT), carried out with monosodium glutamate (MSG) in opaque capsules containing 50 and 100 mgr., was positive in two hours in four of the five children. MSG's mechanism of action is unknown, and though its use is world-wide, no evidence of hypersensitivity with cutaneous symptomatology has been found in any of the studies carried out to date.
本研究介绍了五名因皮肤病变前来就诊的儿童病例，其中检测到对味精（MSG）过敏。四名儿童的就诊原因是荨麻疹；两名儿童的荨麻疹伴有血管性水肿，而第五名儿童患有特应性皮炎和荨麻疹。在四例荨麻疹病例中，病因诊断可能为药物过敏。用含有50毫克和100毫克味精（MSG）的不透明胶囊进行的口服激发试验（OPT），在五名儿童中有四名在两小时内呈阳性。味精的作用机制尚不清楚，尽管它在全球范围内都有使用，但在迄今为止进行的任何研究中，都未发现有皮肤症状的过敏证据。
