Ozawa K, Sato N, Urabe A, Takaku F
Biochem Biophys Res Commun. 1984 Aug 30;123(1):128-32. doi: 10.1016/0006-291x(84)90389-9.
The effects of retinoic acid (RA) on the proliferation and differentiation of normal myeloid progenitor cells (CFU-C) were studied. In general, RA at 10(-10) to 10(-6) M enhanced primary myeloid colony formation in the presence of colony-stimulating factor(s). However, macrophage colony formation was strongly inhibited by RA. This may be related to the finding that RA is able to differentiate bipotential HL-60 cells into granulocytes but not into macrophages. Moreover, secondary colony formation was always suppressed by the addition of RA to the primary cultures. It means that self-renewal capacity of CFU-C was suppressed by RA. This finding suggests that normal myelopoiesis will be suppressed eventually by RA.
