Gadisseux J F, Rodriguez J, Lyon G
Clin Neuropathol. 1984 Jul-Aug;3(4):160-7.
The autopsy findings of a 21/2-year-old microcephalic, mentally retarded girl, with tetraparesis, and dysmorphic features are reported. Neuropathologic findings, typical of the ponto-neocerebellar hypoplasia described by Brun [1917], suggest that this abnormality was the result of a prenatally acquired destruction of the pontine nuclei, with a secondary retrograde degeneration of the dentatopontine tract. The possible role of phenytoin, taken by the mother during pregnancy, is discussed.
报告了一名2岁半小头畸形、智力发育迟缓、四肢瘫痪且有畸形特征女孩的尸检结果。神经病理学发现符合布伦[1917年]所描述的脑桥-新小脑发育不全，提示这种异常是由于产前获得性脑桥核破坏，继发齿状核-脑桥束逆行性变性所致。文中讨论了母亲孕期服用苯妥英钠可能起到的作用。
