Delves H T, Sherlock J C, Quinn M J
Hum Toxicol. 1984 Aug;3(4):279-88. doi: 10.1177/096032718400300404.
The temporal stability of blood lead concentrations of 21 healthy adults (14 men and 7 women) exposed only to environmental lead was assessed by analysis of 253 blood specimens collected serially over periods from 7 to 11 months. Improved analytical sensitivity allowed detection of small (less than 1.0 microgram/100 ml) changes in blood lead concentrations and both within- and between-run analytical errors were minimized by a strict internal quality control protocol. The women had lower blood lead concentrations (mean 8.5, range 7.4-10.8 micrograms/100 ml) than did the men (mean 12.2, range 8.6-15.8 micrograms/100 ml). These are within the expected ranges for non-occupationally exposed persons. Blood lead concentrations in the serial specimens from both men and women changed very little over the study period, with standard deviations of less than 0.5 micrograms/100 ml for the majority of individual mean concentrations: for all except two subjects the standard deviations were less than 0.8 micrograms/100 ml. Two subjects showed significant changes in blood lead concentrations during the study (standard deviations of mean greater than 1.0 micrograms/100 ml). A temporary increase in oral lead intake was identified for one of these subjects. In the absence of substantial changes in lead exposure blood lead levels in adults are remarkably stable and for their environmental monitoring a single blood lead concentration is an excellent biological indicator.
通过对21名仅暴露于环境铅中的健康成年人（14名男性和7名女性）在7至11个月期间连续采集的253份血样进行分析，评估了血铅浓度的时间稳定性。提高的分析灵敏度能够检测出血铅浓度的微小变化（小于1.0微克/100毫升），并且通过严格的内部质量控制方案将批内和批间分析误差降至最低。女性的血铅浓度（平均8.5，范围7.4 - 10.8微克/100毫升）低于男性（平均12.2，范围8.6 - 15.8微克/100毫升）。这些都在非职业暴露人群的预期范围内。在研究期间，男性和女性连续血样中的血铅浓度变化很小，大多数个体平均浓度的标准差小于0.5微克/100毫升：除两名受试者外，所有受试者的标准差均小于0.8微克/100毫升。两名受试者在研究期间血铅浓度出现了显著变化（平均标准差大于1.0微克/100毫升）。其中一名受试者被确定口服铅摄入量暂时增加。在铅暴露没有实质性变化的情况下，成年人的血铅水平非常稳定，对于环境监测而言，单次血铅浓度是一个极佳的生物学指标。
