未经治疗的麸质肠病男性患者对雄激素的可逆性不敏感。

Reversible insensitivity to androgens in men with untreated gluten enteropathy.

作者信息

Green J R, Goble H L, Edwards C R, Dawson A M

出版信息

Lancet. 1977 Feb 5;1(8006):280-2. doi: 10.1016/s0140-6736(77)91825-6.

Abstract

Plasma androgen and gonadotrophin concentrations have been measured before and during treatment of 23 men with gluten enteropathy. Before treatment, there was marked rise in total plasma-testosterone, free testosterone concentration (as assessed by the free testosterone index), and plasma-luteinising-hormone concentration. In contrast, 5 alpha-dihydrotestosterone concentrations were lower than normal. All these abnormalities reverted towards normal with successful treatment of the jejunal mucosal lesion. These data are consistent with a reversible tissue resistance to circulating plasma-testosterone in men with gluten enteropathy and subtotal villous atrophy.

摘要

对23例麸质肠病男性患者在治疗前及治疗期间测定了血浆雄激素和促性腺激素浓度。治疗前，血浆总睾酮、游离睾酮浓度（通过游离睾酮指数评估）及血浆促黄体生成素浓度均显著升高。相比之下，5α - 双氢睾酮浓度低于正常水平。随着空肠黏膜病变的成功治疗，所有这些异常情况均恢复至正常。这些数据与患有麸质肠病和部分绒毛萎缩的男性对循环血浆睾酮存在可逆性组织抵抗相一致。