桂利嗪、赛庚啶、多塞平和羟嗪治疗特发性寒冷性荨麻疹的比较：多塞平的有效性

Comparison of cinnarizine, cyproheptadine, doxepin, and hydroxyzine in treatment of idiopathic cold urticaria: usefulness of doxepin.

作者信息

Neittaanmäki H, Myöhänen T, Fräki J E

出版信息

J Am Acad Dermatol. 1984 Sep;11(3):483-9. doi: 10.1016/s0190-9622(84)70196-4.

Abstract

Randomized double-blind trials using doxepin and several conventional antihistamines were carried out for treatment of patients with idiopathic cold urticaria. In the first double-blind trial, eight of nine patients preferred doxepin (10 mg three times daily) to cinnarizine (10 mg three times daily). In the second double-blind trial, the results of ice cube tests suppressing the effect of cyproheptadine (4 mg three times daily), doxepin (10 mg three times daily), and hydroxyzine (10 mg three times daily) did not statistically differ. However, doxepin was subjectively the most effective and it had fewer side effects than other treatments that were compared. Doxepin effectively suppressed the wheal and itching responses and shortened the duration of the wheal response in the ice cube test in all patients with cold urticaria who were studied.

摘要

使用多塞平和几种传统抗组胺药对特发性寒冷性荨麻疹患者进行了随机双盲试验。在首个双盲试验中，9名患者中有8名更喜欢多塞平（每日3次，每次10毫克）而非桂利嗪（每日3次，每次10毫克）。在第二个双盲试验中，抑制赛庚啶（每日3次，每次4毫克）、多塞平（每日3次，每次10毫克）和羟嗪（每日3次，每次10毫克）作用的冰块试验结果在统计学上无差异。然而，主观上多塞平最为有效，且与所比较的其他治疗相比副作用更少。在所有接受研究的寒冷性荨麻疹患者的冰块试验中，多塞平有效抑制了风团和瘙痒反应，并缩短了风团反应的持续时间。