Greene S L, Reed C E, Schroeter A L
J Am Acad Dermatol. 1985 Apr;12(4):669-75. doi: 10.1016/s0190-9622(85)70092-8.
Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day). All patients had an evaluation that failed to disclose a cause for their disease. Therapeutic response was assessed according to the suppression of symptoms and symptom diary scores of daily itching and frequency, number, size, and duration of hives. Total clearing of the pruritus and urticarial lesions occurred in 43% of the patients while receiving doxepin and in only 5% while receiving diphenhydramine (p less than 0.001). Partial or total control of the pruritus and hives was noted in 74% of the patients receiving doxepin and in only 10% of those receiving diphenhydramine (p less than 0.001). Doxepin induced markedly less sedation (22%) than diphenhydramine (46%) (p less than 0.05). Dermatopathologic categories included (1) urticaria simplex, (2) lymphocytic urticaria, and (3) leukocytoclastic urticaria. Patients with urticaria simplex had a more favorable response to doxepin than the two other groups.
对50例慢性特发性荨麻疹患者进行了研究，以比较多塞平（每日3次，每次10毫克）和苯海拉明（每日3次，每次25毫克）的治疗反应。所有患者的评估均未发现其疾病的病因。根据症状的抑制情况以及每日瘙痒的症状日记评分、荨麻疹的频率、数量、大小和持续时间来评估治疗反应。在接受多塞平治疗的患者中，43%的患者瘙痒和荨麻疹皮损完全消退，而接受苯海拉明治疗的患者中只有5%完全消退（p<0.001）。在接受多塞平治疗的患者中，74%的患者瘙痒和荨麻疹得到部分或完全控制，而接受苯海拉明治疗的患者中只有10%得到控制（p<0.001）。多塞平引起的镇静作用（22%）明显低于苯海拉明（46%）（p<0.05）。皮肤病理类型包括：（1）单纯性荨麻疹，（2）淋巴细胞性荨麻疹，（3）白细胞破碎性荨麻疹。单纯性荨麻疹患者对多塞平的反应比其他两组更有利。
