西索米星和奈替米星单独及与萘夫西林、苯唑西林和甲氧西林联合应用对肠球菌的体外活性。

In vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against enterococci.

作者信息

Watanakunakorn C, Glotzbecker C

出版信息

Chemotherapy. 1978;24(4):236-9. doi: 10.1159/000237787.

Abstract

The in vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against 30 strains of enterococci was investigated. Sisomicin and netilmicin alone were not very effective against enterococci. There was enhanced killing of some strains of enterococci by the combination of sisomicin or netilmicin with one of the three penicillinase-resistant penicillins. Nafcillin was the most effective penicillinase-resistant penicillin in the combination. Sisomicin appeared to be slightly more effective than netilmicin in combination with one of the penicillinase-resistant penicillins against enterococci.

摘要

研究了西索米星和奈替米星单独以及与萘夫西林、苯唑西林和甲氧西林联合对30株肠球菌的体外活性。西索米星和奈替米星单独对肠球菌的效果不太显著。西索米星或奈替米星与三种耐青霉素酶青霉素之一联合使用，可增强对某些肠球菌菌株的杀灭作用。萘夫西林是联合使用中最有效的耐青霉素酶青霉素。在与耐青霉素酶青霉素之一联合使用时，西索米星对肠球菌的效果似乎比奈替米星稍好。